Journal of Pediatric Cardiology and Cardiac Surgery

Online ISSN: 2433-1783 Print ISSN: 2433-2720
Japanese Society of Pediatric Cardiology and Cardiac Surgery
Japanese Society of Pediatric Cardiology and Cardiac Surgery Academy Center, 358-5 Yamabuki-cho, Shinju-ku, Tokyo 162-0801, Japan
Journal of Pediatric Cardiology and Cardiac Surgery 2(1): 28-36 (2018)


Feasibility of In-body Tissue Architecture in Pediatric Cardiovascular Surgery: Development of Regenerative Autologous Tissues with Growth Potential

Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute ◇ Osaka, Japan

受付日:2017年11月20日Received: November 20, 2017
受理日:2017年12月2日Accepted: December 2, 2017
発行日:2018年3月31日Published: March 31, 2018

In-body tissue architecture (IBTA), based on an encapsulation reaction, can produce autologous implantable tissues with desired shape, thickness, and robustness by simply embedding designed molds into subcutaneous pouches for 2 months. Tubular vascular grafts (biotubes), sheet-like patches (biosheets), or valved conduits (biovalves) have been developed for cardiovascular implants. Upon implantation, vascular, myocardial, or valvular tissues were regenerated within several months with high reliability. IBTA first demonstrated evidence of growth potential of biotubes when implanted using a beagle juvenile model. In this review article, we provide an overview of our recent IBTA-based work for pediatric cardiovascular surgery.

Key words: regenerative medicine; tissue engineering; vascular graft; artificial valve; patch membrane

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