Screening for Sudden Cardiac Death in Children: Useful Tool or Wishful Thinking?
Children’s Heart Center, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital ◇ Prague, Czech Republic
The potential for screening young individuals for increased risk of sudden cardiac death has been actively debated within the medical community, as well as in the public. Different views from both sides of the Atlantic on the feasibility and rationality of such an approach are enriching the debate. Data from a Japanese nationwide electrocardiographic screening program on school children provided further valuable insights into this topic. In the following article, evidence on the utility of mass screening, with the inclusion of electrocardiography, is critically discussed.
Key words: sudden cardiac death; children; screening; electrocardiogram
© 2017 特定非営利活動法人日本小児循環器学会© 2017 Japanese Society of Pediatric Cardiology and Cardiac Surgery
Sudden cardiac death (SCD) in a healthy young individual is a highly tragic and emotional event. Especially when happening in a social environment, like during a competition or school sport, broad publicity is highly likely to happen. Public reporting may lead to the impression of a high incidence of SCD in the young and often triggers a debate on the possibility of preventing such tragic cause of death. In particular, those involved in the organization of competitive sport activities are highly motivated to require screening programs that would eliminate this risk.
SCD in the young is a rare event with a low epidemiologic impact. A nationwide study performed in Denmark on patients 1–35 years of age found an annual incidence rate of 2.8 per 100,000 person-years, if the non-autopsied cases were included, and 1.9 per 100,000 person-years, if only the autopsied SCD cases were included. A subgroup analysis on young persons between 1–18 years old revealed an incidence of 1.1 per 100,000 person-years. Most cases of sudden death occurred during sleep (41%) or normal daily activities (41%) and only 16% occurred during moderate and vigorous exercise. Maron et al. pointed out that among high school and college students who had SCD, only 28% were competitive athletes and the remaining 72% were non-athletes. Such data have posed questions on the strategy of focusing only on pre-participation screening in athletes. The incidence of out-of-hospital cardiac arrest in children was highest in infants (72.71 per 100,000), with sudden infant death syndrome as the most common cause, and was much lower in children (3.73 per 100,000) and adolescents (6.37 per 100,000). Therefore, strategies that focus on infants may have a much bigger yield than those applied for older children. The frequency of death from various causes was compared among individuals <25 years of age by Maron et al. Motor vehicular accidents (11,015 per year), homicides (5,717 per year), and suicides (4,189 per year) far outnumbered the cases of death from all causes in athletes (120 per year) and death detectable by electrocardiographic (ECG) screening in National Collegiate Athletic Association athletes (2 per year). These results further questioned the epidemiologic impact of SCD that is specifically associated with competitive sports.
Cardiovascular screening to detect conditions that predispose to SCD in the young includes an accepted, yet unproven, standard consisting of history and physical examination. In the United States, this strategy remains to be a mainstream during pre-participation screening at the least. The other strategies that were suggested and partially evaluated include the 12-lead ECG, echocardiography, and, potentially, genetics. In Europe, based on a single Italian study, electrocardiography has been increasingly used, specifically in pre-participation evaluation, and is sometimes included in the guidelines imposed by national regulators. The Seattle criteria on electrocardiography to specifically detect pathologies in persons aged 14–35 years who are involved in competitive sports have been published and revised several times. Although with improvement over time, the degree of disagreement among over-reading physicians has been significant and reached up to one third of the tracings if both cardiologists and sports physicians were combined in the evaluation group. Pediatricians and pediatric electrophysiologists did not do better on the correct ECG interpretation of different pathologic conditions, which ranged between 70 and 90% ; false-positive results triggered them to prescribe a number of unnecessary diagnostic tests and false-negative results might have led to missed tests. The data derived from these studies casted doubt on the utility of the 12-lead ECG as a universal screening tool with acceptable accuracy for detecting the risk for a very rare condition.
The widely cited Italian study was based on history, physical examination, and resting ECG; derived its data on SCD from a prospective registry; and revealed a significant decrease in the incidence of SCD in athletes after including ECG screening. The study was criticized for its short pre-screening period, which may have missed seasonal variations and the associated immortality bias from an accidental peak in the SCD incidence. Other studies could not show similar results. Specifically, the Israel Sport Law study did not reveal any impact of screening by history, physical examination, and resting and exercise ECG on SCD incidence. The Italian study included 42,386 subjects and generated a positive screening result in 9%, of which 2% had cardiovascular disease and 0.2% had conditions that were potentially lethal to preclude participation in sports. Therefore, in terms of the screening objective, 8.8% had a false-positive result, and the implication was additional costs for evaluation. Other authors have shown that false positivity may be decreased to 2.5% by refinements in the ECG criteria and by training.
The United States National Heart, Lung and Blood Institute working group published in 2011 a Report on Screening for SCD in the Young. The authors have summarized the following general prerequisites for a successful screening program for a given disease condition:
The authors stated that none of the prerequisites has been unequivocally proven for screening for SCD in the young. Should the effect of screening be evaluated by a prospective randomized study, the number of individuals to include would be nearly 8 million, assuming an 80% chance of detecting a change in the end point.
Several studies calculated the cost of screening according to the United States reimbursement conditions. In the report by Leslie et al., the expenses of screening before sports participation at 14 years of age depended on the relative risk of the condition (3.8–1.0 per 100,000 person-years) and ranged between USD 67,495 and USD 574,711 per life-year saved. The generally accepted societal threshold in the United States was set at USD 50,000 to USD 100,000 per life-year.
Based on available data, a scientific statement by the American Heart Association and the American College of Cardiology, endorsed by the Pediatric and Congenital Electrophysiology Society and the American College of Sports Medicine, on the Assessment of the 12-Lead Electrocardiogram as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age) was formulated and included the following:
The recently published European position paper from the EHRA and the EACPR, which are branches of the ESC, on pre-participation cardiovascular evaluation of athletic participants to prevent sudden death stated that
Available studies did not unequivocally support mass ECG screening to decrease the rate of SCD in the young for the following reasons:
The other strategies that may be more effective and cost efficient include:
Future directions include:
Well-controlled studies on defined populations or areas, such as the ECG school screening program in Japan, will provide invaluable data to establish rational screening strategies in the future.
The authors have no conflicts of interest to declare.
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