Journal of Pediatric Cardiology and Cardiac Surgery

Online ISSN: 2433-1783 Print ISSN: 2433-2720
Japanese Society of Pediatric Cardiology and Cardiac Surgery
Japanese Society of Pediatric Cardiology and Cardiac Surgery Academy Center, 358-5 Yamabuki-cho, Shinju-ku, Tokyo 162-0801, Japan
Journal of Pediatric Cardiology and Cardiac Surgery 4(1): 35-41 (2020)

Case ReportCase Report

Neonatal Enterovirus Myocarditis: A Case Report

1Department of Pediatrics, The University of Tokyo ◇ Tokyo, Japan

2Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo ◇ Tokyo, Japan

3National Institute of Infectious Diseases ◇ Tokyo, Japan

受付日:2019年12月12日Received: December 12, 2019
受理日:2020年1月31日Accepted: January 31, 2020
発行日:2020年3月1日Published: March 1, 2020

Neonatal myocarditis is most often caused by enterovirus and has a high mortality of >50%. We report a case of neonatal enterovirus myocarditis. The patient was born at term with a birth weight of 2,637 g. He developed fever on perinatal day 2, and a gallop rhythm was detected by auscultation on day 7. Based on severe left ventricular dysfunction and elevated troponin T, the diagnosis of acute myocarditis was made. Despite inotropic support, his cardiovascular condition deteriorated. He was transferred to a tertiary medical center on day 9 and was further treated with inotropes and mechanical ventilation. On day 30, he was weaned from hemodynamic support and transferred back to the local hospital. Enterovirus was detected in the blood sample taken on day 10 and was thought to be the cause of myocarditis. The test result for neutralizing antibody was negative. Prevention of viral infection during the perinatal period is crucial, given the severity of the disease, requirement of intensive care, and limited treatment options currently available.

Key words: enterovirus; coxsackievirus B; neonatal myocarditis; transplacental antibody; cytokine

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