Pathogenic Variants Associated with Cardiomyopathy in Pediatric Myocarditis as Outcome Predictors

Franziska Seidel; Nele Rolfs; Tobias Hecht; Johanna Hummel; Hendrik Milting; Daniel Messroghli; Stephan Schubert

doi:10.24509/jpccs.23-020

Pathogenic Variants Associated with Cardiomyopathy in Pediatric Myocarditis as Outcome Predictors

Franziska Seidel^1,2,3,4，Nele Rolfs^1,2,4，Tobias Hecht⁵，Johanna Hummel⁵，Hendrik Milting⁶，Daniel Messroghli^2,4,7，Stephan Schubert

⁵Franziska Seidel^1,2,3,4, Nele Rolfs^1,2,4, Tobias Hecht⁵, Johanna Hummel⁵, Hendrik Milting⁶, Daniel Messroghli^2,4,7, Stephan Schubert

⁵

¹ Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease–Pediatric Cardiology ◇ Berlin, Germany

² Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin ◇ Charitéplatz 1, 10117 Berlin, Germany

³ Experimental & Clinical Research Center, a cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association & Charité-Universitätsmedizin Berlin ◇ Germany

⁴ DZHK (German Centre for Cardiovascular Research), partner site Berlin ◇ Germany

⁵ Center for Congenital Heart Disease/Pediatric Cardiology, Heart and Diabetes Center NRW, University Hospital of the Ruhr University Bochum, Medical Faculty OWL (University of Bielefeld) ◇ Germany

⁶ Erich & Hanna Klessmann-Institute, Heart and Diabetescenter NRW, University Clinic of Ruhr University Bochum ◇ Bad Oeynhausen, Germany

⁷ Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine ◇ Berlin, Germany

発行日：2024年7月1日Published: July 1, 2024

Myocarditis in children and adolescents has different courses. Infants and young children suffer more frequently from severe heart failure. In adolescence, on the other hand, patients are more likely to present with chest pain and preserved cardiac function. At the same time, the recovery rate is significantly higher. The influence of disease-associated genetic variants in myocarditis is now widely recognized. Such variants are more common in younger children and in patients with severe heart failure and a phenotype of dilated cardiomyopathy. However, genetic changes have also been described in children with myocarditis and preserved cardiac function, particularly in desmosomal genes. These genetic variants are associated with an increased number of cardiovascular events. This review aims to provide an overview of the impact of genetic variants on the clinical presentation and outcome of pediatric myocarditis.

Key words: myocarditis; pediatric; genetic variants; cardiomyopathy; outcome

Journal of Pediatric Cardiology and Cardiac Surgery

ReviewReview

Pathogenic Variants Associated with Cardiomyopathy in Pediatric Myocarditis as Outcome Predictors